产品目录

分子量：Approximately 15.8kDa,a single non-glycosylated polypeptide chain containing 141 amino acids.
储存条件：冷冻（-20℃）

概述

Human IL-31 gene is located on Chr.12.It expresses the IL-31 protein at low levels in the type 2 helper T cells,which exits in testis,bone marrow,skeletal muscle,kidney,colon,thymus,small intestine and trachea.This protein shares several structural and functional characteristics with IL-6,Oncostatin M,LIF,and Cardiotrophin-1.IL-31 signals through IL-31 receptor A and oncostatin M receptor subunits and can activate STAT3 through receptors and maybe involve in skin immunity.It regulated immune responses have been implicated in skin physiology and inflammatory skin diseases.Human IL-31 shares 24%a.a.sequence identity in the mature protein with mouse IL-31.

使用说明

This material is offered by Biorab Biotech for research,laboratory or further evaluation purposes.NOT FOR HUMAN USE.

技术规格

外观	Sterile Filtered White lyophilized(freeze-dried)powder.
纯度	＞97%by SDS-PAGE and HPLC analyses.
来源	Escherichia coli.
生物活性	Fully biologically active when compared to standard.The specific activity is determined by inducing STAT3 activation using human U-87 MG cells.5ng/mL of rHuIL-31 can effectively induce STAT3 activation.
成分	Lyophilized from a 0.2μmfiltered concentrated solution in PBS,pH7.4.
内毒素	Less than 1 EU/μg of rHuIL-31 as determined by LAL method.
复溶	We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom.Reconstitute in sterile distilled water or aqueous buffer containing 0.1%BSA to a concentration of 0.1-1.0mg/mL.Stock solutions should be apportioned into working aliquots and stored at ≤ -20 ℃.Further dilutions should be made in appropriate buffered solutions.
氨基酸序列	SHTLPVRLLR PSDDVQKIVE ELQSLSKMLL KDVEEEKGVL VSQNYTLPCL SPDAQPPNNI HSPAIRAYLK TIRQLDNKSV IDEIIEHLDK LIFQDAPETN ISVPTDTHEC KRFILTISQQ FSECMDLALK SLTSGAQQAT T

相关搜索：重组人IL-31，IL-31, Human，Recombinant Human Interleukin-31